Author/Authors
Masaru Kitamura، نويسنده , , Kogo Takamiya، نويسنده , , Shinichi Aizawa، نويسنده , , Keiko Furukawa، نويسنده , , Koichi Furukawa، نويسنده ,
DocumentNumber
1601501
Title Of Article
Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice
شماره ركورد
11724
Latin Abstract
We used the knockout mice lacking gangliosides and evaluated their response to tetanus and botulinum toxins. We found that tetanus toxin and botulinum type A or B toxin was less toxic in the knockout mice. We conclude that the toxins bind to the gangliosides on the synapses in the initial step of intoxication prior to penetration of the toxins into the neural cells.
From Page
1
NaturalLanguageKeyword
TETANUS , botulinum , Knockout mouse , Ganglioside , toxin
JournalTitle
Studia Iranica
To Page
3
To Page
3
Link To Document