Author/Authors
Tetsuya Hirabayashi، نويسنده , , Takao Shimizu، نويسنده ,
DocumentNumber
1601676
Title Of Article
Localization and regulation of cytosolic phospholipase A2
شماره ركورد
12012
Latin Abstract
Liberation of arachidonic acid by cytosolic phospholipase A2 (cPLA2) upon cell activation is often the initial and rate-limiting step in leukotriene and prostaglandin biosynthesis. This review discusses the essential features of cPLA2isoforms and addresses intriguing insights into the catalytic and regulatory mechanisms. Gene expression, posttranslational modification and subcellular localization can regulate these isoforms. Translocation of cPLA2α from the cytosol to the perinuclear region in response to calcium transients is critical for the immediate arachidonic acid release. Therefore, particular emphasis is placed on the mechanism of the translocation and the role of the proteins and lipids implicated in this process. The regional distribution and cellular localization of cPLA2 may help to better understand its function as an arachidonic acid supplier to downstream enzymes and as a regulator of specific cellular processes.
From Page
124
NaturalLanguageKeyword
Ca2? , C2 domain , phosphorylation , Isoprenylation , Phosphatidylinositol 4 , 5-bisphosphate , Vimentin
JournalTitle
Studia Iranica
To Page
138
To Page
138
Link To Document