Author/Authors

Kunikazu Tanji، نويسنده , , Tadaatsu Imaizumi، نويسنده , , Tomoh Matsumiya، نويسنده , , Hiroyuki Itaya، نويسنده , , Koji Fujimoto، نويسنده , , Xue-fan Cui، نويسنده , , Tsutomu Toki، نويسنده , , Etsuro Ito، نويسنده , , Hidemi Yoshida، نويسنده , , Koichi Wakabayashi، نويسنده , , Kei Satoh، نويسنده ,

DocumentNumber

1601739

Title Of Article

Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line

شماره ركورد

12130

Latin Abstract

Prostaglandins (PGs) play regulatory roles in a variety of physiological and pathological processes, including the immune response, cytoprotection and inflammation. Desferrioxamine (DFX), an iron chelator, is known to reduce free radical-mediated cell injury and to upregulate certain inflammatory mediators. We investigated the effects of DFX on the production of PGs and the expression of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of PGs, using a human macrophage cell line, U937. Our results showed that COX-2 expression and PGE2 production are upregulated by DFX treatment and that this upregulation is dependent on both COX-2 promoter activity and alteration of mRNA stability. COX-2 promoter activity may be, at least in part, mediated by activation of the extracellular signal-regulated kinase pathway. These findings suggest that iron metabolism may regulate inflammatory processes by modulating PGs as well as other inflammatory mediators

From Page

227

NaturalLanguageKeyword

Iron chelator , Cyclooxygenase , prostaglandin , In£ammation , macrophage , U937

JournalTitle

Studia Iranica

To Page

235

To Page

235