Author/Authors
Celalettin Sever، نويسنده , , Fatih Uygur، نويسنده , , Yalcin KULAHCI، نويسنده , , Gamze TORUN KOSE، نويسنده , , Muammer URHAN، نويسنده , , Zafer KUQUKODACI، نويسنده , , Gunalp Uzun، نويسنده , , Osman iPgiOGLU، نويسنده , , Tuncer QAYCI، نويسنده ,
DocumentNumber
1952529
Title Of Article
Effect of hyperbaric oxygen therapy on bone prefabrication in rats
شماره ركورد
12733
Latin Abstract
Objectives: This experimental study aimed to create a prefabricated vascularized bone graft using the interconnected porous coralline hydroxyapatite ceramic by combining vascular bundle implantation, mesenchymal stem cells, and hyperbaric oxygen therapy (HBOT) administration in a rat model. Methods: Forty-five male Sprague-Dawley rats were divided into three groups, each containing 15 rats. The hydroxyapatite ceramics were vascularized by the superficial inferior epigastric artery and vein in all groups. These vessels passed through the hole of the hydroxyapatite blocks. In Group 2, mesenchymal stem cells were administered into the hydroxyapatite. In Group 3, both mesenchymal stem cells and HBOT were administered. The presence and density of any new bone formation and neovascularization were evaluated by radiography, microangiography, scintigraphy, biochemical analysis, and histomorphometry. Results: Neovascularization and bone formation were significantly greater in Group 3, in which both mesenchymal stem cells and HBOT were applied, than the other groups. Conclusion: HBOT enhances neovascularization and osteogenesis, thus HBOT can provide optimal and faster prefabrication of a vascularized bone graft.
From Page
403
NaturalLanguageKeyword
rat , Hyperbaric oxygen therapy , Bone grafting , hydroxyapatite ceramic
JournalTitle
Studia Iranica
To Page
409
To Page
409
Link To Document