Author/Authors
Karan, M A İstanbul Üniversitesi - Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, Turkey , Tufan, F İstanbul Üniversitesi - İstanbul Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, Turkey
Title Of Article
Mechanisms of aging
شماره ركورد
14655
Abstract
Aging is caused by gradual accumulation of damage in cells and tissues. Accumulation of damage begins early and continues progressively throughout the life. These processes result in loss of adaptive response to stress, in growing risk of age-related diseases, and in the increase in the probability of dying, or age-specific death rate in the population. Much of the damage results from reactive oxygen species; these molecules arise as a side-effect of essential biochemical processes, like the utilization of oxygen to generate chemical energy through oxidative phosphorylation. Multiple genes regulate the efficacy of “longevity-assurance” processes such as DNA repair that together influence the rate of aging. However, some other factors, such as nutrition and environmental temperature, can have important effects in modulating the rate of the accumulation of damage within the body.
From Page
11
NaturalLanguageKeyword
Aging , reactive oxygen species , genetic , nutrition
JournalTitle
Ege Journal Of Medicine
To Page
17
JournalTitle
Ege Journal Of Medicine
Link To Document