Immune Response Against to Asthma

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Both innate and adaptive immune responses develop against to asthma which is characterized by chronic inflammation of the airways. It is known that contacting the products of microorganisms in early period of life changes the T helper (Th) 2 cell response to Th1 response. Basic reseptors of innate immunity are toll-like receptors (TLR). Bronchial epitelial cells are the most important cells that take part in inflammation, these cells act as antigen presenting cells (APC), and they contribute to the airway remodelling by secreting some growth factors. The other cells in innate immunity are; dendritic cells, basophils, mast cells, eosinophils, monocytes, macrophages, platelets. Adaptive immune response occurs as cellular and humoral immunity. It is known for a long time that basic cells in asthma pathogenesis are Th2 cells. But recently it is shown that Th1, Th9, Th17, Th25, folli-cular T cell, regulator T cell, invariant natural killer T cell, and γδ T cell contribute to the pathogenesis.

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Asthma , Innate immune response , Adaptive immun response.

Fırat Medical Journal

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Fırat Medical Journal