Author/Authors
kiliç, nuh adnan menderes üniversitesi - veteriner fakültesi - cerrahi anabilim dalı, Turkey , kozaci, l. didem yıldırım beyazıt üniversitesi - tıp fakültesi - tıbbi biyokimya anabilim dalı, Turkey
Title Of Article
Effects of Flunixine Meglumine, Diclofenac Sodium, Metamizol Sodium and Carprofen on Oxidative Stress in Rats Subjected to Laparotomy
شماره ركورد
18175
Abstract
The aim of this study was to determine the effects of nonsteroid antiinflammatory drugs on oxidative stress in rats subjected to laparotomy. Rats (n=50) were divided into five equal groups. Control group (n=10, Group I) received physiological saline whereas Groups II-V (n=10 in each) received metamizole (50 mg/kg), flunixin meglumine (2.5 mg/kg), carprofen (2.5 mg/kg), or diclofenac (2.5 mg/kg) by intraperitoneal injection for 5 days following the operation. On postoperative day 6, blood samples were obtained; levels of malondialdehyde (MDA) and nitric oxide (NO) in serum, and erythrocyte glutathione (GSH), catalase levels were determined. NSAIDs caused a decrease in MDA, NO and GSH levels, whereas catalase levels increased with NSAID treatment. In conclusion, NSAIDs may have additional beneficial effects to their anti-inflammatory effects by diminishing the oxidative stress.
From Page
75
NaturalLanguageKeyword
Oxidative stress , laparotomy , NSAIDs , rat
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
To Page
78
JournalTitle
Fırat University Veterinary Journal Of Health Sciences
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