Maternal thrombophilia causes at recurrent early pregnancy loss

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Purpose: Genetically transmitted thrombophilias are commonly accused for the recurrent pregnancy losses.Detection of thrombophilia in preconceptional or early prenatal period provides great advantage to obtain healthy pregnancies, especially in places where consanguineous marriages are common. In this study we aimed to evaluate distribution of thrombophilia problems in cases with recurrent pregnancy loss.Materials and methods:In our study, the population was composed of 109 women who admitted to Pamukkale University Faculty of Medicine Obstetrics and Gynecology department with recurrent pregnancy loss and having no abnormality apart from thrombophilia. A questionnaire was administered to obtain information about background history and the results were evaluated statistically.Results: We detected Methyl-tetra-hydra-folate-reductase (MTHFR) heterozygote mutation in 39 (35,8 %), Activated protein C resistance (APC) in 18 (16,5%), Factor V Leiden (FVL) mutation in 17 (15,6%) and MTFHR homozygote mutation in 17 (15,6%) patients out of 109. The most common thrombophilias seen together were FVL heterozygot mutation and APC resistance (%8,3).Conclusion: MTHFR heterozygot mutation was the most frequent thrombophilic abnormality we detected in cases with recurrent pregnancy loss and the most common abnormalities seen together are the FVL heterozygot mutation and APC resistance.

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Recurrent pregnancy loss , maternal thrombophlia , MTHFR , Factor V Leiden

Pamukkale Medical Journal

6

116

2016

Pamukkale Medical Journal