Author/Authors
Eser, Bekir Engin Zirve Üniversitesi - Emine-Bahaeddin Nakıboğlu Tıp Fakültesi - Tıbbi Biyokimya AD, Turkey , Yazgan, Ümit Can Zirve Üniversitesi - Emine-Bahaeddin Nakıboğlu Tıp Fakültesi - Fizyoloji AD, Turkey , Gürses, Serdar Abidin Zirve Üniversitesi - Emine-Bahaeddin Nakıboğlu Tıp Fakültesi - Tıbbi Biyoloji AD, Turkey , Aydın, Mehmet Zirve Üniversitesi - Emine-Bahaeddin Nakıboğlu Tıp Fakültesi - Fizyoloji AD, Turkey
Title Of Article
Diabetes Mellitus and Epigenetic Mechanisms
شماره ركورد
27333
Abstract
Diabetes Mellitus (DM) is an important disease caused by insulin deficiency or insulin receptor resistance and characterized by hyperglycemia. The prevalence rate of DM is increasing rapidly worldwide and its associated complications affect the quality of life of patients adversely. In addition, high medical costs for its treatment bring significant economic load on countries. Epigenetics is the reversible modifications on the genome, which lead to changes in gene expression without any alteration in the DNA sequence. Epigenetic modifications can easily be affected by environmental factors and abnormalities in these modifications have been linked to many diseases including cancer and neurodegenerative disorders. In this review, we will summarize the relationship of DM and its complications with DNA and RNA methylation, which are among the most important modifications.
From Page
375
NaturalLanguageKeyword
Diabetes Mellitus , Epigenetics , DNA methylation
JournalTitle
Dicle Medical Journal
To Page
382
JournalTitle
Dicle Medical Journal
Link To Document