Author/Authors
Bekçi, Taha T. Konya Education and Research Hospital - Clinic of Chest Disease, Turkey , Koçak, Nadir Konya Education and Research Hospital - Clinic of Genetic, Turkey , Özen, Filiz Göztepe Education and Research Hospital - Clinic of Genetic, Turkey , Teke, Turgut Selçuk University - School of Medicine - Department of Chest Disease, Turkey
Title Of Article
The distribution of FV Leiden mutation in patients with obstructive sleep apnea
شماره ركورد
32919
Abstract
Aim. We aimed to investigate whether this polymorphism has any effects on the development of the differences in the progression of the OSAS patients. Methods. The patient group was selected from patients admitted to the our Sleep Laboratory. Total 122 subjects, 44 OSAS patients (only), 32 OSAS patients with cardio vascular diseases (CVD) and 46 controls, were enrolled in the study. The control group consisted of healthy volunteers who had no symptoms of OSAS and scored 0 on the Epworth sleepiness scale. In order to determine gene mutations, DNA isolation was performed from peripheral blood samples. Results. While mean weight and BMI were significantly different, no significant differences were found between patient and control groups in terms of FV Leiden allele distributions. Conclusion. FV Leiden mutation does not affect progression in patients with OSAS
From Page
61
NaturalLanguageKeyword
Obstructive sleep apnea , polymorphism , mutation
JournalTitle
Cumhuriyet Medical Journal
To Page
66
JournalTitle
Cumhuriyet Medical Journal
Link To Document