Effect of postmenopausal hormone treatment on serum lipid profile and coagulation factors

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To assess the effects of different hormone treatment regimes on blood lipids, lipoproteins, ATIII, fibrinogen in postmenopausal patients. We studied retrospectively 115 patients who recieved one of four different estrogen treatment protocols. Of the 115 patiens; 25 had received transdermal estradiol patch 3.9 mg/week(TD) (Group-1), 22 patients had received TD + MPA 2.5 (Group-2), 19 patients had received oral CEE 0.625 mg/day (Group-3), 23 patients had received CEE 0.625 mg/day + MPA 2.5 mg/day (Group-4), 26 postmenopausal patients who had no hormonal treatment composed control group. Plasma cholesterol, lipids, lipoproteins, ATIII, and fibrinogen levels before and 6 months after treatment were checked from their recordings retrospectively. Serum cholesterol level increased in control group, decreased in MPA taking Group-2, and Group-4. Serum LDL level decreased significantly in Group 2, 3, and 4 while it increased insignificantly in control group. Serum HDL level increased significantly only in oral CEE taking Group-3 (24% increase). Trigliseride level significantly decreased in Group-2 (10.1% decrease). Fibrinogen decreased in all treatment groups, ATIII did not change in treatment groups but increased in control group by 22.9%.Estrogen alone or in combination with progestin effects plasma lipid levels in a positive way. It also decreases fibrinogen level that might be protective for CVD.

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Hormone Replacement Treatment Menopause Lipid Profile Coagulation Factor Postmenopusal Period

Journal Of Experimental an‎d Clinical Medicine

103

Journal Of Experimental an‎d Clinical Medicine