Author/Authors
KOÇAR ÇELİK, Sibel Afyon Kocatepe Üniversitesi - Tıp Fakültesi - Biyokimya AD Afyonkarahisar, Turkey , KAHRAMAN, Ahmet Afyon Kocatepe Üniversitesi - Tıp Fakültesi - Biyokimya AD Afyonkarahisar, Turkey , MARALCAN, Gökhan Afyon Kocatepe Üniversitesi - Tıp Fakültesi - Ortopedi ve Travmatoloji A D, Turkey
Title Of Article
Effect Of Hyaluronic Acide On Oxidative Stress And Inflammation Which Have Role In Pathogenesis Of Osteoarthritis
شماره ركورد
42012
Abstract
The aim: Owing to the finding and symptoms which lead to deformation and physical disability, ostearthritis (OA) reduces the patient’s life quality. Much treatment that is used to increase the life quality of the patients is directed towards to symptoms. They provide symptomatic recovery. There is a need for protective treatment that reduces the ruin of the main cartilage and increases the anabolism of cartilage. Condroprotective medicines provide the regression of the disease and slow the progression down. Hyluronic acid (HA) has been used for this aim. In this study, we have aimed to determine effects of HA application to patients with osteoarthritis (OA) on inflammation and oxidative stress that has role in pathogenesis of OA. Materials and methods: It was applied intraarticularly three doses of HA to patients with OA (n=8) Joint fluid has been obtained with injector before application of HA (control group) and after application of third doses (treatment group). The levels of malondialdehyde (MDA) which is a product of lipid peroxidation, reduced glutathione (GSH) and protein sulphydryl groups (SH groups) which indicate antioxidant capacity, tumor necrosis factor- α (TNF- α) as an indicator of inflammatory process and the content of protein carbonyl in the joint fluid of control group and treatment group have been estimated. Results: It was observed that decreased MDA (p 0.05), carbonyl (p 0.01) and TNF-α (p 0.01) levels and increased GSH (p 0.05) levels in treatment group significantly. It was determined the mild increase in protein SH groups. But it was not a significant increase, statistically (p 0.05). Conclusion: We consider that HA therapy have positive effects associated with a decrease MDA, carbonyl and TNF-α levels, a rises on SH and GSH levels in the joint fluid on pathogenesis of OA.
From Page
1
NaturalLanguageKeyword
Osteoartritis , hyaluronic asid , inflammation , oxidative stress.
JournalTitle
Kocatepe Medical Journal
To Page
7
JournalTitle
Kocatepe Medical Journal
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