Determining The Influence of Regional Differences and Maternal Factors on The Triple Test

42143

Objective: Second-trimester maternal serum screening has become a routine part of prenatal care. We aimed to identify if triple test measurements were affected by regional differences and maternal factors. We compared our results with the results of a previous study on Turkish population, and with the values of the manufacturer firm. Material and Methods: The study group consisted of 984 pregnant women between 14–22 weeks of gestation who had undergone a triple test. The original PRISCA software was used for calculating the statistical risk. Results: Comparison of median values for serum AFP, between published Turkish population, manufacturer values and Gaziantep population were: 1% between Gaziantep population and Turkish population, and 3 % between Gaziantep population and manufacturer values in 16. gestational week; 5 % and 4 % in 17. gestational week; 13 % and 14 % in 18. gestational week, respectively. 19. gestational week showed no difference. Same comparison for β-hCG showed; 5 % and 1 % in 16. gestational week; 4 % and 2 % in 17. gestational week; 13 % and 1 % in 18. gestational week; 1 % and 24 % in 19. gestational week, respectively. Comparison for uE3 values showed; 36 % and 95 % in 16. gestational week; 39 % and 89 % in 17. gestational week; 25 % and 67 % in 18. gestational week; 34 % and 72 % in 19. gestational week, respectively. Conclusion: This study showed that, screening tests may vary based on regional differences. Our study presents a potential risk factor that may be an explanation for some problems with the triple test evaluations in some laboratories.

124

Triple test , risk factors , regional differences , PRISCA

Kocatepe Medical Journal

130

Kocatepe Medical Journal