Author/Authors
hajib, sara sidi mohamed ben abdellah university - center of doctoral studies “sciences and technology”, faculty of sciences dhar mahraz, FES, Morocco , aouine, younas ibn zohr university - faculty of sciences - department of chemistry, Agadir, Morocco , aouine, younas sidi mohammed ben abdellah university - faculty of sciences dhar el mahraz - organic chemistry laboratory (lco), FES, Morocco , alami, anouar sidi mohammed ben abdellah university - faculty of sciences dhar el mahraz - organic chemistry laboratory (lco), FES, Morocco , faraj, hassane sidi mohammed ben abdellah university - faculty of sciences dhar el mahraz - organic chemistry laboratory (lco), FES, Morocco , bekkari, hicham sidi mohammed ben abdellah university - faculty of sciences dhar el mahraz - laboratory of biotechnologies (lb), FES, Morocco
Title Of Article
SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIBACTERIAL ACTIVITY STUDY OF 4-[(1H-PYRAZOL-1- YL)METHYL]-4-METHYL-2-PHENYL-4,5-DIHYDROOXAZOLE
شماره ركورد
45171
Abstract
The compound, 4-[(1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5- dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyl oxazoline derivative 1 and a pyrazolic compound, by heating in DMSO in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy (^1H, ^13C) and MS data. The synthesized product was tested in vitro for its antibacterial activity against Gram-positive and Gram-negative bacteria (S. aureus, B. subtilis, Streptococcus, P. aeruginosa, E. coli).
From Page
70
NaturalLanguageKeyword
antibacterial activity , pyrazole , N , alkylation
JournalTitle
Journal Marocain De Chimie Hétérocyclique
To Page
76
JournalTitle
Journal Marocain De Chimie Hétérocyclique
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