Transformations and algorithms in a computerized brain atlas

The computerized brain atlas (CBA) at the Karolinska Hospital, Stockholm, is designed to be employed in different fields of neuro imaging. The atlas aids the interpretation of functional images by introducing anatomical information, to serve as a tool in the merging of data from different imaging modalities, and to facilitate the comparisons of data from different individuals by allowing for anatomical standardization of individual data. The algorithms and transformations used in the implementation of the atlas software are described. The CBA method uses a contour-based approach for the individualization of the atlas brain. Stereotactic standardization is then achieved using nonlinear resampling determined by the function adapting the atlas to the individual