A viral envelope as a vehicle for tracer, drug, and gene delivery

Author

Flexman, J.A. ; Minoshima, S. ; Yongmin Kim ; Miyoshi, Shigeki ; Lewellen, B.L. ; Cross, D.J.

Author_Institution

Dept. of Bioeng., Washington Univ., Seattle, WA

Volume

25

Issue

4

fYear

2006

Firstpage

70

Lastpage

75

Abstract

Gene and drug encapsulation by a viral vector administered via a systemic injection represents a therapeutic delivery system that is noninvasive and can potentially be targeted to a region of the body. However, an effective way of monitoring biodistribution, both acutely and over the long term, is needed to evaluate new targeting technologies and to tailor patient care in the clinic. A sensitive and dynamic method is needed to compare the effect of various approaches on clearance. Positron emission tomography (PET) imaging can detect radiotracers within the body with high sensitivity, and, in this study, the noninvasive tracking of viral vectors tagged with radioactive fluorine ([F-18]fluoride) is presented

Keywords

drug delivery systems; genetics; patient care; positron emission tomography; radioactive tracers; PET; biodistribution monitoring; drug delivery; gene delivery; noninvasive viral vector tracking; patient care; positron emission tomography; radioactive fluorine; radiotracer detection; therapeutic delivery system; tracer detection; viral envelope; Biomembranes; Blood; Drugs; Encapsulation; In vivo; Liver; Magnetic resonance imaging; Patient monitoring; Positron emission tomography; Vehicle dynamics;

fLanguage

English

Journal_Title

Engineering in Medicine and Biology Magazine, IEEE

Publisher

ieee

ISSN

0739-5175

Type

jour

DOI

10.1109/MEMB.2006.1657790

Filename

1657790