• DocumentCode
    1092513
  • Title

    Evolvable social agents for bacterial systems modeling

  • Author

    Paton, Ray ; Gregory, Richard ; Vlachos, Costas ; Saunders, Jon ; Wu, Henry

  • Author_Institution
    BioComput. & Comput. Biol. Res. Group, Univ. of Liverpool, UK
  • Volume
    3
  • Issue
    3
  • fYear
    2004
  • Firstpage
    208
  • Lastpage
    216
  • Abstract
    We present two approaches to the individual-based modeling (IbM) of bacterial ecologies and evolution using computational tools. The IbM approach is introduced, and its important complementary role to biosystems modeling is discussed. A fine-grained model of bacterial evolution is then presented that is based on networks of interactivity between computational objects representing genes and proteins. This is followed by a coarser grained agent-based model, which is designed to explore the evolvability of adaptive behavioral strategies in artificial bacteria represented by learning classifier systems. The structure and implementation of the two proposed individual-based bacterial models are discussed, and some results from simulation experiments are presented, illustrating their adaptive properties.
  • Keywords
    ecology; evolution (biological); genetics; microorganisms; molecular biophysics; physiological models; adaptive behavioral strategies; bacterial ecologies; bacterial evolution; bacterial systems modeling; coarse grained agent-based model; evolvable social agents; fine-grained model; genes; individual-based modeling; learning classifier systems; proteins; Artificial intelligence; Biological system modeling; Biology computing; Computational biology; Computational modeling; Computer architecture; Computer science; Environmental factors; Evolution (biology); Microorganisms; Adaptation, Physiological; Artificial Intelligence; Bacterial Physiology; Bacterial Proteins; Computer Simulation; Directed Molecular Evolution; Environment; Gene Expression Regulation; Models, Biological; Signal Transduction; Systems Biology;
  • fLanguage
    English
  • Journal_Title
    NanoBioscience, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    1536-1241
  • Type

    jour

  • DOI
    10.1109/TNB.2004.833701
  • Filename
    1331346