DocumentCode
1132340
Title
Charged Magnetic Nanoparticles for Enhancing Gene Transfection
Author
Wang, Xiaoliang ; Zhou, Linzhu ; Ma, Yongjie ; Gu, Hongchen
Author_Institution
Med-X Inst., Shanghai Jiao Tong Univ., Shanghai
Volume
8
Issue
2
fYear
2009
fDate
3/1/2009 12:00:00 AM
Firstpage
142
Lastpage
147
Abstract
Magnetite nanoparticles were surface modified with five kinds of agents and used to enhance gene transfection. Standard polyethyleneimine (PEI) transfections were found to be enhanced only for the magnetic nanoparticles with strong surface potentials, since these can form complexes with PEI or genes via electrostatic interactions. Thus, it is not necessary to prepare gene-vector-coated magnetic nanoparticles for magnetofection.
Keywords
biochemistry; bioelectric potentials; biomagnetism; cellular biophysics; gene therapy; magnetic particles; molecular biophysics; nanoparticles; nanotechnology; polymers; proteins; surface potential; PEI; charged magnetite nanoparticles; electrostatic interaction; gene transfection enhancement; magnetofection; polyethyleneimine transfection; surface potential; Magnetic nanoparticles; magnetofection; polyethyleneimine (PEI);
fLanguage
English
Journal_Title
Nanotechnology, IEEE Transactions on
Publisher
ieee
ISSN
1536-125X
Type
jour
DOI
10.1109/TNANO.2009.2013946
Filename
4768726
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