Examination of the exciting condition for the high-temperature magnetic hyperthermia

Author

Sawaya, Yukiko ; Suzuki, Nobutake ; Sato, Fumihiro ; Matsuki, Hidetoshi ; Aiba, Setsuya ; Sato, Tadakuni

Author_Institution

Dept. of Electr. & Commun. Eng., Graduate Sch. of Tohoku Univ., Sendai, Japan

Volume

41

Issue

10

fYear

2005

Firstpage

4161

Lastpage

4163

Abstract

The soft-heating method is one of the hyperthermia. The heater that consists of thermosensitive ferrite is implanted into the body, and heated by a high-frequency magnetic field. This paper applies the "advanced" soft-heating method. A complex type of heater, composed of thermosensitive ferrite wound on a metallic ring, is created. This complex type of heater produces heat due to losses of hysteresis and inductive current. The effect of the exciting frequency on the heating value of a complex type of heater is examined. As a result, the area of 12×7 mm is heated over 60°C in phantom, in the condition of 6 mT-100 kHz. The heated area in vitro is confirmed, so a test in vivo is examined. The tumors of mice were heated to the point at which the tumor is necrotized.

Keywords

biological effects of fields; ferrites; hyperthermia; hysteresis; magnetic fields; tumours; 100 KHz; 12 mm; 6 mT; 7 mm; complex type heater; exciting frequency effect; heating value; high-frequency magnetic field; hysteresis loss; inductive current; magnetic hyperthermia; soft-heating method; thermosensitive ferrite; tumors; Ferrites; Frequency; Heating; Hyperthermia; Imaging phantoms; In vitro; Magnetic fields; Magnetic hysteresis; Neoplasms; Wounds; Exciting condition; hyperthermia; soft-heating method; thermosensitive ferrite;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2005.854859

Filename

1519567