Model Studies with the Inversely Calculated lsochrones of Ventricular Depolarization

This paper describes experimental studies on the influence of inhomogeneities in the volume conductor, and model errors and measurement errors on the inversely calculated isochrones of ventricular depolarization. The results indicate that in the inverse problem the use of inhomogeneous models is essential, that knowledge of the exact heart geometry (shape and orientation) is important, and that signal error (noise) as encountered in normal ECG recordings is not critical. The number of (measurement) leads required is found to be on the order of 64.