Cerebrospinal Impedance Response to Induced Epileptic Activit

Impedance levels in the cerebrospinal fluid in cats were measured prior to and during epileptic seizures. Seizures were induced with an intramuscular injection of penicillin during general anesthesia. Impedance levels were elevated to twice the threshold value up to 15 min prior to the onset of seizure activity. Seizures were monitored with a depth EEG electrode. The detection of a significant measurable preseizure event will aid in the development of an early warning detector to alert epileptics of an impending seizure. The millions of epileptics who cannot be treated surgically or pharmaceutically would not have to severely restrict their activities, as they would have ample warning of the onset of a seizure. This study is undertaken to develop the detection method to use in such a device.