The Haemodynamics of Endovascular Aneurysm Treatment: A Computational Modelling Approach for Estimating the Influence of Multiple Coil Deployment

Author

Kakalis, N.M.P. ; Mitsos, A.P. ; Byrne, J.V. ; Ventikos, Y.

Author_Institution

Dept. of Eng. Sci., Oxford Univ., Oxford

Volume

27

Issue

6

fYear

2008

fDate

6/1/2008 12:00:00 AM

Firstpage

814

Lastpage

824

Abstract

This paper proposes a novel computational methodology for modelling the haemodynamic effects of endovascular coil embolization for cerebral aneurysms. We employ high-resolution 3-D angiographic data to reconstruct the intracranial geometry and we model the coiled part of the aneurysm as a porous medium, with porosity decreasing as coils are inserted. The actual dimensions of the coils employed are used to determine the characteristics of the porous medium. Simulation results for saccular aneurysms from the anterior communicating and middle cerebral arteries show that insertion of coils rapidly changes intraaneurysmal blood flow and causes reduction in mural pressure and blood velocity up to stagnation, providing favorable conditions for thrombus formation and obliteration of the aneurysm.

Keywords

blood; blood vessels; brain; diseases; flow simulation; haemodynamics; neurophysiology; patient treatment; porosity; aneurysm; blood velocity; cerebral aneurysms; cerebral arteries; endovascular aneurysm treatment; endovascular coil embolization; haemodynamics; intraaneurysmal blood flow; intracranial geometry reconstruction; multiple coil deployment; mural pressure; porosity; porous medium; rotational angiography; saccular aneurysms; stagnation; thrombus formation; Aneurysm; Arteries; Biomedical engineering; Blood flow; Brain modeling; Coils; Computational fluid dynamics; Computational modeling; Embolization; Hemorrhaging; Cerebral aneurysms; computational haemodynamics; embolization; porous media; rotational angiography; Blood Flow Velocity; Blood Pressure; Cerebral Angiography; Cerebral Arteries; Computer Simulation; Computer-Aided Design; Embolization, Therapeutic; Equipment Design; Equipment Failure Analysis; Humans; Imaging, Three-Dimensional; Intracranial Aneurysm; Models, Cardiovascular; Therapy, Computer-Assisted; Treatment Outcome;

fLanguage

English

Journal_Title

Medical Imaging, IEEE Transactions on

Publisher

ieee

ISSN

0278-0062

Type

jour

DOI

10.1109/TMI.2008.915549

Filename

4531637