Confidence maps and confidence intervals for near infrared images in breast cancer

Author

Tosteson, Tor D. ; Pogue, Brian W. ; Demidenko, Eugene ; McBride, Troy O. ; Paulsen, Keith D.

Author_Institution

Dartmouth Med. Sch., Hanover, NH, USA

Volume

18

Issue

12

fYear

1999

Firstpage

1188

Lastpage

1193

Abstract

Extends basic concepts of statistical hypothesis testing and confidence intervals to images generated by a new procedure for near infrared spectroscopic tomography being developed for use in breast cancer diagnosis. By estimating the covariance matrix of the pixels of an image from data used in the image reconstruction process, confidence maps for statistical tests on individual pixels and confidence intervals for entire images are displayed as an aid to research and clinical personnel interpreting possibly noisy images. The methods are applied to simulated and phantom-based images.

Keywords

cancer; image reconstruction; infrared imaging; infrared spectroscopy; mammography; medical image processing; statistical analysis; IR spectroscopic tomography; breast cancer; confidence intervals; confidence maps; medical diagnostic imaging; near infrared images; noisy images interpretation; phantom-based images; simulated images; statistical tests; Breast cancer; Covariance matrix; Image generation; Image reconstruction; Infrared imaging; Infrared spectra; Pixel; Spectroscopy; Testing; Tomography; Breast Neoplasms; Computer Simulation; Confidence Intervals; Diagnosis, Differential; Female; Humans; Image Processing, Computer-Assisted; Phantoms, Imaging; Spectroscopy, Near-Infrared; Tomography;

fLanguage

English

Journal_Title

Medical Imaging, IEEE Transactions on

Publisher

ieee

ISSN

0278-0062

Type

jour

DOI

10.1109/42.819328

Filename

819328