In-beam PET imaging for the control of heavy-ion tumour therapy

Author

Pawelke, J. ; Enghardt, W. ; Haberer, Th ; Hasch, B.G. ; Hinz, R. ; Krämer, M. ; Lauckner, K. ; Sobiella, M.

Author_Institution

Inst. fur Kern- und Hadronenphys., Forschungszentrum Rossendorf, Dresden, Germany

Volume

44

Issue

4

fYear

1997

fDate

8/1/1997 12:00:00 AM

Firstpage

1492

Lastpage

1498

Abstract

A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distributions of β⁺-emitters generated by nuclear fragmentation during the irradiation and their relation to the dose. In order to study this relationship and to derive the dose distribution from the measured β⁺-activity distribution, a framework of model calculations is used. Results of phantom experiments with ¹²C ion beams are presented, demonstrating good agreement between experiment and calculation as well as the possibilities and limits of the PET-technique for treatment plan verification and beam monitoring

Keywords

biocontrol; dosimetry; ion beam applications; positron emission tomography; radiation therapy; β⁺-emitters; ¹²C ion beams; C; beam monitoring; dose distribution; dynamic spatial distribution; heavy-ion tumour therapy control; in-beam PET imaging; in-situ control method; model calculations framework; nuclear fragmentation; phantom experiments; treatment plan verification; Biomedical applications of radiation; Ion beams; Magnetic variables control; Medical treatment; Monitoring; Nuclear power generation; Particle beams; Positron emission tomography; Shape; Tumors;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.632694

Filename

632694