An original emission tomograph for in vivo brain imaging of small animals

Author

Valva Ochos, A. ; Ploux, L. ; Mastrippolito, R. ; Charon, Y. ; Lanièce, P. ; Pinot, L. ; Valentin, L.

Author_Institution

Inst. de Phys. Nucl., Univ. de Paris-Sud, Orsay, France

Volume

44

Issue

4

fYear

1997

fDate

8/1/1997 12:00:00 AM

Firstpage

1533

Lastpage

1537

Abstract

The principle of a new tomograph (TOHR) dedicated for small volume analysis with very high resolution is presented. The authors use uncorrelated multi-photon (X- or gamma rays) radioisotopes and a large solid angle focusing collimator to produce tomographic images without a reconstruction algorithm. With this device, detection efficiency and resolution are independent and submillimeter resolution can be achieved. A feasibility study shows that collimators made with a stack of chemically etched plates can achieve the predicted performances of TOHR. The authors discuss its potential in rat brain tomography by simulating a realistic neuropharmacological experiment using a 1.4 mm resolution prototype of the TOHR under development

Keywords

biological techniques; brain; emission tomography; chemically etched plates stack; detection efficiency; emission tomograph; in vivo brain imaging; large solid angle focusing collimator; nuclear medicine research; realistic neuropharmacological experiment; small animals; small volume analysis; submillimeter resolution; uncorrelated multiphoton radioisotopes; Brain; Collimators; Focusing; Gamma rays; High-resolution imaging; In vivo; Optical imaging; Radioactive materials; Solids; Tomography;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.632717

Filename

632717