DocumentCode
1312221
Title
In Silico Search of DNA Drugs Targeting Oncogenes
Author
Papadakis, George ; Gizeli, Electra
Author_Institution
Dept. of Biol., Univ. of Crete, Heraklion, Greece
Volume
9
Issue
6
fYear
2012
Firstpage
1826
Lastpage
1830
Abstract
Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.
Keywords
DNA; RNA; cancer; drugs; genetics; molecular biophysics; DNA drugs; antigene therapy; mRNA synthesis level; oncogenes; target sequences; triplex forming oligonucleotides; Bioinformatics; Cancer; DNA; Encoding; Genomics; Stability analysis; Antigene therapy; oncogenes; transcription inhibition; triplex forming oligos; Animals; Antineoplastic Agents; Base Sequence; Computer Simulation; DNA; Drug Discovery; Gene Targeting; Humans; Mice; Molecular Sequence Data; Molecular Targeted Therapy; Nucleic Acid Conformation; Oligonucleotides; Oncogenes; RNA, Messenger; Sequence Analysis, DNA; Transcription, Genetic;
fLanguage
English
Journal_Title
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
Publisher
ieee
ISSN
1545-5963
Type
jour
DOI
10.1109/TCBB.2012.127
Filename
6327180
Link To Document