DocumentCode
1339766
Title
Effect of chitosan-polyvinyl alcohol blend nanofibrous web on the healing of excision and incision full thickness wounds
Author
Kanani, A.G. ; Bahrami, S. Hajir ; Taftei, H.A. ; Rabbani, Shahram ; Sotoudeh, M.
Author_Institution
Textile Eng. Dept., Amirkabir Univ. of Technol., Tehran, Iran
Volume
4
Issue
4
fYear
2010
fDate
12/1/2010 12:00:00 AM
Firstpage
109
Lastpage
117
Abstract
Chitosan-polyvinyl alcohol (PVA) blend nanofibrous webs were fabricated in different blend ratios through electrospinning procedures. From scanning electron microscopy (SEM) results, 25/75 blend ratio of chitosan-PVA was selected for biological studies. In vivo studies were carried out on the dorsum of rats of two types: longitudinal incisional wounds (n = 8 rats) and round excisional wounds (n = 8). Pathological study was done on the wounds to investigate the healing process. The histological study in wound healing indicated that the administration of chitosan nanofibrous web improved the wound healing, qualitatively and quantitatively.
Keywords
biological tissues; biomedical materials; first aid; nanobiotechnology; polymer blends; SEM; chitosan-PVA; chitosan-polyvinyl alcohol blend nanofibrous web; electrospinning; excision full thickness wounds; histological study; incision full thickness wounds; pathological study; rat dorsum; wound healing;
fLanguage
English
Journal_Title
Nanobiotechnology, IET
Publisher
iet
ISSN
1751-8741
Type
jour
DOI
10.1049/iet-nbt.2010.0004
Filename
5591552
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