Interaction between microspheres of collagen/biphasic calcium phosphate and mesenchymal stem cells

Author

Wei Zhang ; Yun Zeng ; Peng Wei ; Zhiyong Wang ; Jian Lu ; Qingrong Wei ; Gang Liu

Author_Institution

Affiliated Hosp., Dept. of Orthopedics, North Sichuan Med. Coll., Nanchong, China

Volume

7

Issue

12

fYear

2012

fDate

12/1/2012 12:00:00 AM

Firstpage

1217

Lastpage

1219

Abstract

Collagen has been widely used as biomaterials for its excellent biocompatibility and the potential to guide tissue regeneration. Based on the inducing regeneration concept, collagen/biphasic calcium phosphate microspheres (BCP) were prepared by utilising emulsion polymerisation and the intrinsic self-assembly of collagen. The bioactivity of the micro collagen/BCP composites was preliminarily evaluated by in vitro co-culture with mesenchymal stem cells (MSCs) and the results indicated that the composites can provide an appropriate environment for the proliferation and osteogenic differentiation of MSCs and have a potential clinical application in the bone tissue engineering field.

Keywords

biochemistry; biomedical materials; bone; calcium compounds; cellular biophysics; composite materials; emulsions; microfabrication; molecular biophysics; polymerisation; proteins; self-assembly; tissue engineering; Ca₃(PO₄)₂; bioactivity; biocompatibility; biomaterials; biphasic calcium phosphate; bone tissue engineering; cell proliferation; emulsion polymerisation; inducing regeneration concept; intrinsic self-assembly; mesenchymal stem cells; microcollagen/BCP composites; microspheres; osteogenic differentiation; tissue regeneration;

fLanguage

English

Journal_Title

Micro & Nano Letters, IET

Publisher

iet

ISSN

1750-0443

Type

jour

DOI

10.1049/mnl.2012.0452

Filename

6419597