In the Spotlight: Cardiovascular Engineering

Author

Trayanova, Natalia

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

Volume

4

fYear

2011

fDate

7/3/1905 12:00:00 AM

Firstpage

14

Lastpage

16

Abstract

In this paper, a computational approach for predicting the effects of anti-arrhythmic therapy, which was informed and validated with experimental data that defined key measurable parameters necessary to simulate the interaction kinetics of the anti-arrhythmic drugs flecainide and lidocaine with cardiac sodium channels.

Keywords

biomedical measurement; biomedical optical imaging; cardiovascular system; drug delivery systems; drugs; electrocardiography; medical image processing; optical tomography; tissue engineering; ECG; antiarrhythmic drugs; antiarrhythmic therapy; biomedical imaging; cardiac sodium channels; cardiovascular engineering; computational approach; flecainide; interaction kinetics; lidocaine; measurable parameters; optical coherence tomography; Cardiovascular system; Defibrillation; Drugs; Electrocardiography; Heart; In vivo; Tomography; Arrhythmias, Cardiac; Cardiovascular System; Electric Countershock; Electrocardiography; Electron Microscope Tomography; Humans; Models, Cardiovascular; Myocardium; Sodium Channels;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Reviews in

Publisher

ieee

ISSN

1937-3333

Type

jour

DOI

10.1109/RBME.2011.2172832

Filename

6125652