Pole-assignment self-tuning control of blood pressure in postoperative patients: a simulation study

Pole-placement self-tuning control applied to the management of hypertensive patients following surgery is considered via extensive simulation studies on a clinically evaluated model. This model has complexities involving a recirculation term and two threshold-switchable reflex loops due to angiotensin and epinephrine. In this work, further extensions have been made to include drug saturation effects, time-varying patient gains and drug concentration changes. Results are also shown for the self-tuner performance in the presence of coloured noise as obtained from clinical trials. Providing the pole-placement self tuner is jacketed during initial start-up and under sudden transitions, it is shown to perform adequately in simulations of this medical application.