DocumentCode
1450910
Title
Magnetic Microactuator for Controlling Nanoparticles in Gene Delivery Applications
Author
Flick, Eva ; Belski, Alexander ; Li, Wenzhong ; Steinhoff, Gustav ; Gatzen, Hans H.
Author_Institution
Center for Production Technol., Leibniz Univ. Hannover, Garbsen, Germany
Volume
45
Issue
10
fYear
2009
Firstpage
4869
Lastpage
4872
Abstract
Magnetic force-enhanced gene delivery provides a promising method for an efficient transfection even to single cells. Conjugating genes with magnetic nanoparticles allows for the magnetic manipulation of these complexes. This paper presents the concept, modeling, and fabrication technology for a magnetic microactuator designed as a pole row for magnetically actuating these complexes. For conducting preliminary tests, a scaled-up model of the micro pole row was created.
Keywords
bioMEMS; cellular biophysics; electromagnetic actuators; gene therapy; magnetic particles; medical control systems; microactuators; microfabrication; nanoparticles; fabrication technology; magnetic force-enhanced gene delivery; magnetic manipulation; magnetic microactuator design; magnetic nanoparticle control; micro pole row; single cell transfection; Magnetic MEMS; microactuator; single stem cell transfection; thin-film technology;
fLanguage
English
Journal_Title
Magnetics, IEEE Transactions on
Publisher
ieee
ISSN
0018-9464
Type
jour
DOI
10.1109/TMAG.2009.2025669
Filename
5257269
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