Source prebiasing for improved second harmonic bubble-response imaging

The use of the second harmonic bandwidth in order to improve the contrast enhancement of vascular space provided by microbubble echo contrast is well established. A significant obstacle to improving on the contrast advantage of the second harmonic bandwidth arises from the linear response of tissue to the finite amplitude distortion produced second harmonic in the beam. A scheme in which the source wave contains a second harmonic component designed to cancel out the second harmonic produced by finite amplitude distortion in the focal region was computationally investigated. This prebiasing scheme was found to offer significant reductions in the amplitude of the second harmonic in the focal region. These reductions were found in both the homogeneous tissue path case and in the inhomogeneous tissue path case. The resulting clinical potential of source prebiasing is discussed. Also, it was observed that the inhomogeneous focusing of the finite amplitude distortion-produced second harmonic was significantly better than that of a same frequency fundamental with an identical homogeneous path focal profile.