Toward the development of miniaturized imaging systems for detection of pre-cancer

Author

Descour, Michael R. ; Kärkkäinen, Ari H O ; Rogers, Jeremy D. ; Liang, Chen ; Weinstein, Ronald S. ; Rantala, Juha T. ; Kilic, Bahattin ; Madenci, Erdogan ; Richards-Kortum, Rebecca R. ; Anslyn, Eric V. ; Dupuis, Russell D. ; Schul, Randy J. ; Willison, C

Author_Institution

Dept. of Aerosp. & Mech. Eng., Arizona Univ., Tucson, AZ, USA

Volume

38

Issue

2

fYear

2002

fDate

2/1/2002 12:00:00 AM

Firstpage

122

Lastpage

130

Abstract

In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre-cancer. The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro-machined silicon microoptical table. Optical elements have been printed in a negative tone hybrid glass to a maximum depth of 59 μm and an rms surface roughness between 10-45 nm, fulfilling the requirements of the miniature microscope. Test optical elements have been assembled using silicon-spring equipped mounting slots. The design of silicon springs is presented in this paper. Optical elements can be assembled within the tolerances of an NA=0.4 miniature microscope objective, confirming the concept of simple, zero-alignment assembly

Keywords

bio-optics; biomedical equipment; biomedical imaging; cancer; fluorescence; micro-optics; microlenses; micromachining; optical fabrication; optical microscopes; photolithography; sol-gel processing; binary photomask; bulk micromachined microoptical table; dichroic beam-splitter; hybrid sol-gel materials; hybrid sol-gel method; lenslets; lithographically printed optics; medical imaging; microassembly; miniature microscope; miniaturized imaging systems; negative tone hybrid glass; optical-sectioning fluorescence microscope; photolithography; precancer detection; refractive lenses; silicon-spring equipped mounting slots; zero-alignment assembly; Assembly; Biomedical imaging; Biomedical optical imaging; Fluorescence; Focusing; Glass; Optical imaging; Optical microscopy; Rough surfaces; Silicon;

fLanguage

English

Journal_Title

Quantum Electronics, IEEE Journal of

Publisher

ieee

ISSN

0018-9197

Type

jour

DOI

10.1109/3.980264

Filename

980264