A novel tissue engineering electrospun-PLGA for potential application in tendon repair

Author

Chen, J.P. ; Yeh, Mei-Ling ; Nien, Y.H.

Author_Institution

Inst. of Biomed. Eng., Nat. Cheng Kung Univ., Tainan

fYear

2009

Firstpage

1

Lastpage

2

Abstract

The treatment of the rupture tendon is still an obstacle in respect of suture method. Therefore, such shortcoming in repairing fracture tendons could be overcome through tissue engineering approaches. The aim of present study is to investigate the influence of processing parameters on PLGA scaffold morphology and fiber diameters and the effect of the tendon fibroblast with the obtained novel tissue engineering electrospun-PLGA. The nanofiber scaffold was produced via electrospinning. The result shows that the nanofiber diameter and morphology could be controlled under different processing parameters. The Achilles tendon fibroblasts exhibit enough cell viability and were attached with spindle shape on the PLGA nanofiber scaffold. Therefore, PLGA nanofiber scaffold have the potential for Achilles tendon repair.

Keywords

biomechanics; biomedical materials; bone; cellular biophysics; electrospinning; nanobiotechnology; nanofibres; polymers; tissue engineering; Achilles tendon fibroblasts; PLGA scaffold morphology; cell viability; electrospun-PLGA; fiber diameters; nanofiber scaffold; suture method; tendon repair; tissue engineering; Biological materials; Biomedical engineering; Chemical technology; Fibroblasts; Morphology; Optical fiber testing; Scanning electron microscopy; Tendons; Tissue engineering; Voltage; PLGA nanofiber; electrospinning; tendon fibroblasts; tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2009 IEEE 35th Annual Northeast

Conference_Location

Boston, MA

Print_ISBN

978-1-4244-4362-8

Electronic_ISBN

978-1-4244-4364-2

Type

conf

DOI

10.1109/NEBC.2009.4967803

Filename

4967803