Decreased Lempel-Ziv complexity in Alzheimer´s disease patients´ magnetoencephalograms

Author

Gómez, Carlos ; Hornero, Roberto ; Abásolo, Daniel ; López, Miguel ; Fernández, Alberto

Author_Institution

E.T.S. Ingenieros de Telecomunicacion, Valladolid Univ.

fYear

2006

Firstpage

4514

Lastpage

4517

Abstract

The aim of the present research is to study the magnetoencephalogram (MEG) background activity in patients with Alzheimer´s disease (AD) using the Lempel-Ziv (LZ) complexity. We recorded the MEG with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D Neuroimaging) in 10 patients with probable AD and 10 age-matched control subjects, during five minutes. Artefact-free epochs were selected for the non-linear analysis. In all MEG channels, the AD patients had lower complexity than control subjects. In 77 of them the differences were statistically significant (p < 0.01). These preliminary results suggest that cognitive dysfunction in AD is associated with a decreased complexity in certain regions of the brain

Keywords

cognition; diseases; magnetoencephalography; medical signal processing; Alzheimer disease; MEG; artefact-free epochs; brain; cognitive dysfunction; decreased Lempel-Ziv complexity; magnetoencephalogram background activity; nonlinear analysis; whole-head magnetometer; Alzheimer´s disease; Degenerative diseases; Dementia; Electroencephalography; Magnetic analysis; Magnetometers; Neuroimaging; Senior citizens; Telecommunications; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1615472

Filename

1615472