Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: a simulation study

Author

Saiz, J. ; Ferrero, J.M., Jr. ; Chorro, J. ; Monserrat, M. ; Torres, V. ; Ferrero, J.M. ; Thakor, N.V.

Author_Institution

Univ. Politecnica de Valencia, Spain

fYear

1997

Firstpage

709

Lastpage

712

Abstract

The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. The authors´ results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast I_Na current may be partially responsible for the ERP prolongation

Keywords

bioelectric phenomena; cardiology; cellular biophysics; digital simulation; medical computing; physiological models; Luo-Rudy phase II model; Na; cardiac electrophysiology; cellular electrical behavior; computer model; fast I_Na current; refractoriness prolongation; simulation study; subthreshold high-frequency stimuli trains; ventricular tissue segment; Application software; Biomedical computing; Biomedical engineering; Cardiology; Computer simulation; Delay; Enterprise resource planning; Frequency; Hospitals; Medical simulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1997

Conference_Location

Lund

ISSN

0276-6547

Print_ISBN

0-7803-4445-6

Type

conf

DOI

10.1109/CIC.1997.648149

Filename

648149