Experiment studies of iodinated oil nanometer ferrofluid retention in rabbit liver

To study possibility for iodinated oil nanometer ferrofluid retention in rabbit liver. ¹³¹I-iodinated oil nanometer ferrofluid were injected into liver right lobe through portal vein in 5 rabbits. gamma-calibrate meter showed continuous gamma counts in the region injected. Then the relative metabolic parameters were calculated. Left lobe livers, right lobe livers and lungs of the rabbits were examined in pathology, and the right lobe livers were examined by electron microscope. Five rabbits injected purely ¹³¹I-iodinated oil were designated as control group. Single metabolic mode was found in the rabbits in nanometer ferrofluid group. The biological half-life of ¹³¹I-iodinated oil nanometer ferrofluid was not different from control group´s slow metabolic portion. But control group´s rapid metabolic portion were eliminated in a higher speed, range from 8% to 44%. More damage was found in nanometer ferrofluid group´s right lobe livers. ¹³¹I-iodinated oil nanometer ferrofluid possess the opportunity of local retention in human body and further study is worthwhile