Chemical bionics - a novel design approach using Ion Sensitive Field Effect Transistors

Author

Georgiou, Pantelis ; Toumazou, Chris

Author_Institution

Inst. of Biomed. Eng., Imperial Coll. London, London

fYear

2008

Firstpage

229

Lastpage

232

Abstract

This paper introduces Chemical Bionics in which the biochemical physiology of cells in the body are implemented in VLSI to make novel bio-inspired therapeutic devices. As an example, the glucose dependant electrophysiology of the pancreatic beta cell is implemented in silicon to form a novel bio-inspired prosthetic for glucose homeostasis of Type I diabetes. For this, the Ion Sensitive Field Effect Transistor (ISFET) is shown as a suitable chemical sensing front end, which allows CMOS monolithic implementation, as well as low power weak-inversion operation.

Keywords

CMOS integrated circuits; VLSI; biochemistry; bioelectric potentials; biological organs; biomedical electronics; biomedical equipment; biosensors; cellular biophysics; chemical sensors; diseases; integrated circuit design; ion sensitive field effect transistors; low-power electronics; prosthetics; silicon; CMOS chemical sensor; CMOS monolithic implementation; ISFET; Si; bio-inspired prosthetics; bio-inspired therapeutic device; biochemical VLSI; biochemical physiology; chemical bionics; chemical sensing front end; glucose dependant electrophysiology; glucose homeostasis; ion sensitive field effect transistor; low power weak-inversion operation; pancreatic beta cell; silicon metabolic cells; type I diabetes; Biosensors; Chemical sensors; Chemical technology; FETs; Humans; Neurons; Pancreas; Silicon; Sugar; Very large scale integration;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference, 2008. BioCAS 2008. IEEE

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4244-2878-6

Electronic_ISBN

978-1-4244-2879-3

Type

conf

DOI

10.1109/BIOCAS.2008.4696916

Filename

4696916