• DocumentCode
    1655794
  • Title

    Preparation and Anticoagulant Activity of Sulfated 6-Carboxychitosan

  • Author

    Yang, Yuedong ; Zhou, Yongguo ; Hou, Wenlong ; Zhao, Yongguang ; Ren, Yanjun

  • Author_Institution
    Dept. of Chem., Hebei Normal Univ. of Sci. & Technol., Qinhuangdao
  • fYear
    2008
  • Firstpage
    982
  • Lastpage
    985
  • Abstract
    6-Carboxychitosan (6-CC), prepared by selectively oxidization of chitosan powder with NO2 gas in glacial acetic acid, was sulfated with chlorosulfoni acid in formamide to give sulfated 6-carboxylchitosan (S6CC). In S6CC, -SO3H groups were primarily grafted on -NH2, next on secondary -OH, and thirdly on -CH2OH positions. Sodium salt of S6CC (Na-S6CC) was more similar with heparin sodium than sulfated chitosan in both structure and anticoagulation activity.
  • Keywords
    biomedical materials; blood; materials preparation; organic compounds; anticoagulant activity; blood coagulant factors; chitosan powder; chlorosulfoni acid; formamide; glacial acetic acid; grafting; hemolytic property; heparin sodium; oxidization; sodium salt; sulfated 6-carboxychitosan; Blood; Chemical technology; Chemistry; Ethanol; Government; Ice; Infrared spectra; Powders; Spectroscopy; Temperature;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
  • Conference_Location
    Shanghai
  • Print_ISBN
    978-1-4244-1747-6
  • Electronic_ISBN
    978-1-4244-1748-3
  • Type

    conf

  • DOI
    10.1109/ICBBE.2008.241
  • Filename
    4535121
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1655794