Design of a Novel Acid-Sensing Biosensor Based on Taste Neurons and LAPS

Author

Peihua Chen ; Gong Cheng ; Bingqing Wang ; Ping Wang

Author_Institution

Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou

fYear

2008

Firstpage

1561

Lastpage

1564

Abstract

A novel biosensor based on the platform of neuron- silicon interface was designed and characterized. Taste receptor cells cultured on light addressable potentiometric sensor (LAPS) can recognize sour stimuli as compared with non-acid solutions. A computational model of taste receptor cells was constructed to simulate the ionic currents and action potentials of taste receptor cells, to help decode extracellular signals recorded by LAPS. This study provides the prototype of a novel biosensor which deploys the sensory transduction and decoding mechanism from biology to realize chemosensing, potentially in a noninvasive and long- term manner.

Keywords

biosensors; chemioception; potentiometers; acid sensing biosensor; action potentials; extracellular signals; ionic current; light addressable potentiometric sensor; sensory transduction; taste neurons; taste receptor cells; Biological system modeling; Biology computing; Biosensors; Cells (biology); Computational modeling; Decoding; Neurons; Sensor phenomena and characterization; Silicon; Taste buds;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.719

Filename

4535599