A CMOS bio-impedance measurement system

Author

Yufera, Alberto ; Rueda, Adoración

Author_Institution

Centro Nac. de Microelectron. (CNM-CSIC), Univ. de Sevilla, Sevilla

fYear

2009

Firstpage

252

Lastpage

257

Abstract

This paper proposes a new method for bio-impedance measurement useful to 2D processing of cell cultures. It allows to represent biological samples by using a new impedance sensing method, and exploiting the electrode-to-cell model for both electrical simulation and imaging reconstruction. Preliminary electrical simulations are reported to validate the proposal for electrical cell impedance spectroscopy (ECIS) applications. The results reported show that low concentration cell culture can be correctly sensed and displayed at several frequencies using the proposed CMOS system.

Keywords

CMOS integrated circuits; biomedical electrodes; biomedical electronics; cellular biophysics; electric impedance imaging; electric impedance measurement; image reconstruction; medical image processing; 2D processing; CMOS bio-impedance measurement system; ECIS; biological samples; electrical cell impedance spectroscopy; electrical simulation; electrode-to-cell model; imaging reconstruction; impedance sensing method; low-concentration cell culture; Biological system modeling; CMOS image sensors; Circuit simulation; Electric variables measurement; Electrodes; Image reconstruction; Impedance measurement; Optical imaging; Optical sensors; Semiconductor device modeling; Bioimpedance; CMOS analog circuits; bio-instrumentation; biometric circuits; sensory systems;

fLanguage

English

Publisher

ieee

Conference_Titel

Design and Diagnostics of Electronic Circuits & Systems, 2009. DDECS '09. 12th International Symposium on

Conference_Location

Liberec

Print_ISBN

978-1-4244-3341-4

Electronic_ISBN

978-1-4244-3340-7

Type

conf

DOI

10.1109/DDECS.2009.5012140

Filename

5012140