Effect of polymer composition on in vivo ultrasound contrast agent performance

Author

Lathia, Justin D. ; Le, Ngocyen T. ; El-Sherif, Dalia ; Forsberg, Fleming ; Jin-Bin Liu ; Merton, D.A. ; Shimiz, M. ; Goldberg, B.B. ; Wheatley, M.A.

Author_Institution

Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA

fYear

2003

Firstpage

323

Lastpage

324

Abstract

Polymer composition, the ratio of lactic acid (LA) to glycolic acid (GA), was evaluated for its contribution to the acoustic enhancement of a poly (co-lactic-glycolic) acid (PLGA) ultrasound contrast agent. Contrast agents were prepared from four different polymer compositions (LA:GA): 100:0, 85:15, 75:25, 50:50 and tested in vivo. The results indicate that all contrast agents perform well in vivo but the 50:50, which had the shortest usable life-time. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.

Keywords

biomedical materials; biomedical ultrasonics; image enhancement; medical image processing; polymers; acoustic enhancement; in vivo ultrasound contrast agent performance; lactic acid; medical diagnostic imaging; poly co-lactic-glycolic acid; polymer composition; usable life-time; Acoustic testing; Biomedical acoustics; Biomedical engineering; Chemical engineering; Degradation; In vivo; Polymers; Rabbits; System testing; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216126

Filename

1216126