A silicon nanowire-based bio-sensing system with digitized outputs for acute myocardial infraction diagnosis

Silicon nanowire-based biosensors have been identified as a promising biosensing technology. However, it suffers from the interface signal process to be applied into applications. In this paper, we utilize a readout circuit to directly transfer the signal obtained from a Si nanowire based sensing device into digital format. Based on the experimental results, cTnI and NT-proBNP, the biomarkers for acute myocardial infraction diagnosis, can be detected by the developed bio-sensing system in different concentration (320fM, 32pM, 3.2nM and 32nM). As a consequence, this work demonstrates the potential to translate Si nanowire biosensors device into applied bio-sensing systems.