Causal interactions between thalamic and cortical LFPs following hypoxic-ischemic brain injury

Author

Dan Wu ; Bezerianos, A. ; Sherman, D. ; Xiaofeng Jia ; Thakor, N.V.

Author_Institution

Sch. of Med., Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

fYear

2011

fDate

April 27 2011-May 1 2011

Firstpage

184

Lastpage

187

Abstract

Asphyxial cardiac arrest (CA) introduces a global hypoxic-ischemic insult to the brain and disturbs the neural networks. We analyzed the thalamocortical interactions in a rat model of asphyxial CA, using the local field potentials recorded from the thalamus and cortex during CA and the recovery periods. The direct Directed Transfer Function (dDTF) and Directed Information Flow (DIF) were applied to characterize the causal coherence and causal mutual information of the network, respectively. Key results from dDTF and DIF analyses suggest from complementary perspectives that the thalamus may play a leading role in arousal in an ischemic brain.

Keywords

bioelectric potentials; brain; causality; injuries; neurophysiology; asphyxial cardiac arrest; causal coherence; causal mutual information; cortical LFP; direct directed transfer function; directed information flow; hypoxic-ischemic brain injury; local field potentials; neural networks; thalamic LFP; thalamocortical interactions; Anesthesia; Brain modeling; Coherence; Electroencephalography; Medical diagnostic imaging; Rats; Transfer functions;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2011 5th International IEEE/EMBS Conference on

Conference_Location

Cancun

ISSN

1948-3546

Print_ISBN

978-1-4244-4140-2

Type

conf

DOI

10.1109/NER.2011.5910518

Filename

5910518