A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing

Author

Xiwei Huang ; Fei Wang ; Jing Guo ; Mei Yan ; Yu Hao ; Kiat Seng Yeo

Author_Institution

Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore, Singapore

fYear

2014

fDate

10-13 June 2014

Firstpage

1

Lastpage

2

Abstract

A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps.

Keywords

CMOS image sensors; DNA; biosensors; ion sensitive field effect transistors; semiconductor device noise; CMOS ion-image sensor; accurate high-throughput DNA sequencing; correlated double sampling readout; dual-mode sensing; ion-sensitive field-effect transistor; local pH; optical contact imaging; pixel-to-pixel ISFET threshold voltage mismatch; standard CMOS image sensor; suppressed fixed-pattern-noise; Arrays; CMOS integrated circuits; DNA; Sensitivity; Sensors; Sequential analysis; Standards; CDS; CIS; DNA sequencing; ISFET; contact imaging; pH detection;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits Digest of Technical Papers, 2014 Symposium on

Conference_Location

Honolulu, HI

Print_ISBN

978-1-4799-3327-3

Type

conf

DOI

10.1109/VLSIC.2014.6858409

Filename

6858409