Sherlock´s Toolkit: A forensic DNA analysis system

Author

Ricke, D. ; Shcherbina, A. ; Chiu, N. ; Schwoebel, E. ; Harper, J. ; Petrovick, M. ; Boettcher, T. ; Zook, C. ; Bobrow, J. ; Wack, E.

Author_Institution

Bioeng. Syst. & Technol. Group, MIT Lincoln Lab., Lexington, MA, USA

fYear

2015

fDate

14-16 April 2015

Firstpage

1

Lastpage

10

Abstract

DNA sequence analysis has multiple forensic applications. The justice system currently uses sizes of STRs as well as mitochondrial DNA (mtDNA) for DNA evidence. With recent advancements in DNA sequencing technologies, inclusion of additional polymorphic loci, including SNPs, enable new useful analyses while maintaining backwards compatibility with STR sizing. Sherlock´s Toolkit, developed by MIT Lincoln Laboratory, is an open source, scalable system for the integration and automation of STR and SNP-based analysis for high-throughput sequence data. The toolkit includes modules for a range of kinship, biogeographic ancestry, replicate, and mixture analyses.

Keywords

DNA; bioinformatics; forensic science; public domain software; DNA evidence; DNA sequence analysis; DNA sequencing technologies; SNP-based analysis; STR sizing; Sherlock Toolkit; backwards compatibility; biogeographic ancestry; forensic DNA analysis system; forensic applications; high-throughput sequence data; justice system; kinship; mitochondrial DNA; mixture analyses; mtDNA; open source scalable system; polymorphic loci; replicate analyses; Algorithm design and analysis; DNA; Forensics; Sequential analysis; Sociology; Statistics; Support vector machines; DNA mixture; Forensics; SNP; biogeographic ancestry; kinship;

fLanguage

English

Publisher

ieee

Conference_Titel

Technologies for Homeland Security (HST), 2015 IEEE International Symposium on

Conference_Location

Waltham, MA

Print_ISBN

978-1-4799-1736-5

Type

conf

DOI

10.1109/THS.2015.7225306

Filename

7225306