Robotic micro-assembly of scaffold/cell constructs with a shape memory alloy gripper

Describes an integrated approach to design and fabricate scaffold/cell constructs for tissue engineering. With this approach it becomes possible to produce scaffolds with controlled distribution of living cells and growth factors, a critical condition for successful grafting. Our idea consists of building a scaffold/cell construct by robotic micro-assembly of microscopic polymer building blocks. The paper introduces the rationale and concept of this interdisciplinary project and presents some realized steps. A 3D contact FEM simulation has been carried out to study the forces involved on the scaffold elements and micro-gripper during assembly. An error analysis has been performed to evaluate the accumulated error when building a scaffold/cell construct. A dedicated monolithic shape memory alloy micro-gripper has been realized and tested, which is able to handle parts in the range of 50-100 microns.