Epigenetic changes are induced following exposure of peripheral blood cells to CW 800MHz radiation

Author

Korenstein, Rafi ; Mazor, Ronit ; Barbul, Alex ; Korenstein-Ilan, Avital

Author_Institution

Dept. of Physiol. & Pharmacology, Tel-Aviv Univ., Tel-Aviv, Israel

fYear

2011

fDate

13-20 Aug. 2011

Firstpage

1

Lastpage

2

Abstract

Genetic and epigenetic changes are involved in initiation and progression of cancer. We exposed peripheral blood cells from young male volunteers to CW 800MHz radiation at SAR values of 2.9 and 4.1 W/kg for 24 hours (n=5) and 72 hours (n=10). Control experiments were carried out in the temperature range of 33.5-40°C. Epigenetic changes were monitored by analysis of FISH patterns of centromeres of chromosomes 11 and 17 reflecting alteration in their replication timing and synchrony. Our results demonstrate radiation induced non-thermal effect on the level of asynchronous replication in both chromosomes following exposure to the higher SAR level.

Keywords

biological effects of radiation; blood; cancer; cellular biophysics; genetics; CW 800MHz radiation; FISH patterns; asynchronous replication; cancer progression; epigenetic changes; higher SAR level; peripheral blood cells; radiation induced nonthermal effect; temperature 33.5 degC to 40 degC; Blood; Cells (biology); Genetics; Marine animals; Temperature measurement; Timing;

fLanguage

English

Publisher

ieee

Conference_Titel

General Assembly and Scientific Symposium, 2011 XXXth URSI

Conference_Location

Istanbul

Print_ISBN

978-1-4244-5117-3

Type

conf

DOI

10.1109/URSIGASS.2011.6051342

Filename

6051342