Simulation Studies on the Dynamics of Insulin-glucose in Diabetic Mellitus Patients

Glucose-insulin interaction in an insulin-dependent diabetic patient has been simulated using an overall model based on pharmacokinetic diagrams of insulin and glucose. Model is capable of predicting the blood glucose and insulin levels, total glucose uptake and the renal glucose excretion. The treatment strategy is based on a four-daily dose of regular insulin, which is applied through a subcutaneous route 30 min prior to each meal.