Viscoelastic measurements on perfused and non-perfused swine renal cortex in vivo

Author

Amador, Carolina ; Urban, Matthew W. ; Kinnick, Randall ; Chen, Shigao ; Greenleaf, James F.

Author_Institution

Dept. of Physiol. & Biomed. Eng., Mayo Clinic Coll. of Med., Rochester, MN, USA

fYear

2010

fDate

11-14 Oct. 2010

Firstpage

1530

Lastpage

1533

Abstract

Renal fibrosis threatens kidney viability and fibrosis has been associated with altered tissue structure affecting the biomechanical properties of the kidney, such as elasticity and viscosity. Although there are limited studies regarding viscoelastic properties of renal tissue, an in vivo renal MRE study suggests that shear elasticity changes as a result of hemodynamic variables. A newly emerging method called Shearwave Dispersion Ultrasound Vibrometry (SDUV) offers a tool to determine renal elasticity and viscosity in vivo. SDUV quantifies both elasticity and viscosity by evaluating dispersion of shear wave propagation speed versus its frequency. The purpose of this study is to evaluate the feasibility of SDUV for in vivo measurements of elasticity and viscosity on normal swine kidney consequent to acute changes in renal hemodynamics.

Keywords

biological tissues; biomechanics; biomedical measurement; biomedical ultrasonics; diseases; elasticity; haemodynamics; kidney; ultrasonic measurement; vibration measurement; viscoelasticity; viscosity; biomechanical properties; elasticity; hemodynamics; kidney viability; renal fibrosis; shear elasticity; shear wave propagation speed; shearwave dispersion ultrasound vibrometry; swine renal cortex; viscoelastic measurement; viscosity; Animals; Dispersion; Elasticity; In vivo; Kidney; Ultrasonic imaging; Viscosity; Renal cortex; elasticity; viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2010 IEEE

Conference_Location

San Diego, CA

ISSN

1948-5719

Print_ISBN

978-1-4577-0382-9

Type

conf

DOI

10.1109/ULTSYM.2010.5935672

Filename

5935672